A Novel Laboratory-Based Model to Predict the Presence of Obstructive Coronary Artery Disease.

Commonly used tools to assess the probability of obstructive-coronary artery disease (CAD) were derived based on Caucasian cohorts, with their performance in China is still unknown.

Furthermore, most were established based on non-laboratory variables, contributing to the limited predictive ability to some extent. Thus, we developed and internally validated a laboratory-based model with data from a Chinese cohort of 8963 inpatients, with suspected stable chest pain, referred to catheter-based coronary angiography (CAG) from September 2007 to April 2019, and then compared the present model’s performance with the four most commonly used prediction tools, Coronary Artery Disease Consortium 1/2 Score (CAD1/2), Duke clinical score (DCS), and Diamond-Forrester score (DF).

The final model was developed by random forest method, including 8 predictors derived from 70 variables. Five-fold cross-validation was performed to evaluate the model’s prediction accuracy. In the external validation set, the present model showed a superior area under the receiver-operating curve (0.816), followed by DCS (0.66), CAD2 (0.61), CAD1 (0.59) and at last DF (0.58), respectively.

Furthermore, the present model correctly classified 74.4% of obstructive-CAD patients as high-risk, and correctly classified more than one third of non-obstructive-CAD patients as low-risk.

The present model’s net reclassification improvement (NRI) showed a significant positive reclassification over CAD1 (NRI = 0.60, P < 0.001), DF (NRI = 0.59, P < 0.001), CAD2 (NRI = 0.57, P < 0.001), and DCS (NRI = 0.43, P < 0.001). Decision curve analysis demonstrated that the present model provided a larger net benefit compared with CAD1/2, DCS, and DF.

XMIRXpress lentivector miRNA-222-3p with Xmotif

XMIRXP-222 10 ug
EUR 677
  • Category: Exosome

Mouse pre-microRNA Expression Construct mir-222

MMIR-222-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

TA 02

B4924-10 10 mg
EUR 299

TA 02

B4924-5.1 10 mM (in 1mL DMSO)
EUR 177

TA 02

B4924-50 50 mg
EUR 1095

TA-02

B1215-25
EUR 566

TA-02

B1215-5
EUR 185

PU 02

B5687-10 10 mg
EUR 229

PU 02

B5687-25 25 mg
EUR 476

PU 02

B5687-5 5 mg
EUR 144

PU 02

B5687-50 50 mg
EUR 806

UCN-02

C4829-1 1 mg
EUR 460
Description: UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].

UCN-02

C4829-5 5 mg
EUR 1488
Description: UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].

TA-02

HY-100115 10mM/1mL
EUR 404

UCN-02

HY-108262 1mg
EUR 727

UCN-02

U006-1MG 1 mg
EUR 331

UCN-02

U006-5MG 5 mg
EUR 1082

OXF BD 02

B4918-10 10 mg
EUR 350

OXF BD 02

B4918-50 50 mg
EUR 1314

ELX-02 disulfate

HY-114231B 5mg
EUR 567

ELX-02 sulfate

HY-114231C 10mg
EUR 911

1961358-02-0

TBW00994 10mg Ask for price

145867-02-3

TBZ1279 unit Ask for price

Monoclonal LST1 Antibody (clone LST1/02), Clone: LST1/02

APR12482G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human LST1 (clone LST1/02). The antibodies are raised in Mouse and are from clone LST1/02. This antibody is applicable in WB and IHC-P, ICC, IP

VX-222 (VCH-222, Lomibuvir)

A4032-10 10 mg
EUR 305
Description: VX-222, a derivative of thiophene-2-carboxylic acid, is a potent non-nucleoside inhibitor (NNI) of the hepatitis C virus (HCV) RNA polymerase, an enzyme regulating RNA synthesis by a de novo-initiated mechanism or by extension from a primed template.

VX-222 (VCH-222, Lomibuvir)

A4032-100 100 mg
EUR 1186
Description: VX-222, a derivative of thiophene-2-carboxylic acid, is a potent non-nucleoside inhibitor (NNI) of the hepatitis C virus (HCV) RNA polymerase, an enzyme regulating RNA synthesis by a de novo-initiated mechanism or by extension from a primed template.

VX-222 (VCH-222, Lomibuvir)

A4032-5 5 mg
EUR 189
Description: VX-222, a derivative of thiophene-2-carboxylic acid, is a potent non-nucleoside inhibitor (NNI) of the hepatitis C virus (HCV) RNA polymerase, an enzyme regulating RNA synthesis by a de novo-initiated mechanism or by extension from a primed template.

VX-222 (VCH-222, Lomibuvir)

A4032-50 50 mg
EUR 838
Description: VX-222, a derivative of thiophene-2-carboxylic acid, is a potent non-nucleoside inhibitor (NNI) of the hepatitis C virus (HCV) RNA polymerase, an enzyme regulating RNA synthesis by a de novo-initiated mechanism or by extension from a primed template.

JH-VIII-157-02

HY-112140 10mM/1mL
EUR 744

Anti-07/02/07

STJ501223 100 µg
EUR 476

VX-222

B2207-25
EUR 675

VX-222

B2207-5
EUR 207

VX-222

E1KS1480 5mg
EUR 874

QX 222

B6565-10 10 mg
EUR 171

QX 222

B6565-50 50 mg
EUR 470

VX-222

HY-75800 10mM/1mL
EUR 201

5-IAF [5-Iodoacetamidofluorescein] *CAS 63368-54-7*

222 25 mg
EUR 219
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12171501

miRZip-222 anti-miR-222 microRNA construct

MZIP222-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Monoclonal HLA-E Antibody (clone MEM-E/02), Clone: MEM-E/02

AMM01781G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human HLA-E (clone MEM-E/02). The antibodies are raised in Mouse and are from clone MEM-E/02. This antibody is applicable in WB and IHC-P

Monoclonal HLA-E Antibody (clone MEM-E/02), Clone: MEM-E/02

AMM02314G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human HLA-E (clone MEM-E/02). The antibodies are raised in Mouse and are from clone MEM-E/02. This antibody is applicable in WB and IHC-P

Septin 2 (Sep-02) Antibody

20-abx306884
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Septin 2 (Sep-02) Antibody (HRP)

20-abx306885
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Septin 2 (Sep-02) Antibody (FITC)

20-abx306886
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Septin 2 (Sep-02) Antibody (Biotin)

20-abx306887
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

BTK (Ab-222) Antibody

33121-100ul 100ul
EUR 252

BTK (Ab-222) Antibody

33121-50ul 50ul
EUR 187

MAP2K3 (Ab-222) Antibody

33236-100ul 100ul
EUR 252

MAP2K3 (Ab-222) Antibody

33236-50ul 50ul
EUR 187

MAP2K3 (Ab-222) Antibody

CSB-PA084775-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against MAP2K3 (Ab-222). Recognizes MAP2K3 (Ab-222) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:50-1:200

MAP2K3 (Ab-222) Antibody

CSB-PA084775-100ul 100ul
EUR 316
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against MAP2K3 (Ab-222). Recognizes MAP2K3 (Ab-222) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:50-1:200

Cytokeratin 222 Pseudogene antibody

70R-4160 50 ug
EUR 467
Description: Rabbit polyclonal Cytokeratin 222 Pseudogene antibody raised against the N terminal of KRT222P

MEK1 (pS218 / 222) Antibody

abx031877-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

MEK1 (pS218 / 222) Antibody

abx031877-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

MAPK3 (pY205 / 222) Antibody

abx333481-100ul 100 ul
EUR 467
  • Shipped within 5-10 working days.

rno-miR-222 Primers

MP-r00149 150 ul / 10 uM
EUR 176

hsa-miR-222 Primers

MPH01282 150 ul / 10 uM
EUR 121

mmu-miR-222 Primers

MPM00254 150 ul / 10 uM
EUR 121

Indo-1, AM *CAS 112926-02-0*

21030 1 mg
EUR 132
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Indo-1, AM *CAS 112926-02-0*

21033 50 mg
EUR 2181
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Z-IETD-AFC *CAS 219138-02-0*

13425 5 mg
EUR 158
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Mouse Anti Escherichia Coli 02 Monoclonal Antibody

DMABT-51244ME 0.2 mg
EUR 741

Cytokeratin 222 Pseudogene Blocking Peptide

33R-2575 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KRT222P antibody, catalog no. 70R-4160

Phospho-MAPK3 (Tyr205/222) Antibody

CSB-PA213371-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodie
  • Show more
Description: A polyclonal antibody against Phospho-MAPK3 (Tyr205/222). Recognizes Phospho-MAPK3 (Tyr205/222) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-MAPK3 (Tyr205/222) Antibody

CSB-PA213371-100ul 100ul
EUR 362
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodie
  • Show more
Description: A polyclonal antibody against Phospho-MAPK3 (Tyr205/222). Recognizes Phospho-MAPK3 (Tyr205/222) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

MAPK1/3 antibody (Tyr205/222)

70R-34647 100 ug
EUR 327
Description: Purified Rabbit polyclonal MAPK1/3 antibody (Tyr205/222)

MEK1/2 antibody (Ser218/222)

70R-34260 100 ug
EUR 327
Description: Rabbit polyclonal MEK1/2 antibody (Ser218/222)

MKK1 / 2 (pS218 / 222) Antibody

20-abx134438
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

BTK (Ab-222) Conjugated Antibody

C33121 100ul
EUR 397

MAP2K3 (Ab-222) Conjugated Antibody

C33236 100ul
EUR 397

Polyclonal MEK1 Antibody (S218/222)

APR06041G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MEK1 (S218/222). This antibody is tested and proven to work in the following applications:

MAP2K1 / MAP2K2 (pS218 / 222) Antibody

20-abx329018
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Transmembrane Protein 222 (TMEM222) Antibody

20-abx302905
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

hsa-miR-222 miRNA Inhibitor

MIH01588 2 x 5.0 nmol
EUR 176

rno-miR-222-3p Primers

MPR00529 150 ul / 10 uM
EUR 176

rno-miR-222-5p Primers

MPR00530 150 ul / 10 uM
EUR 176

hsa-miR-222-3p Primers

MPH02352 150 ul / 10 uM
EUR 121

hsa-miR-222-5p Primers

MPH02353 150 ul / 10 uM
EUR 121

mmu-miR-222 miRNA Antagomir

MNM01544 2 x 5.0 nmol
EUR 329

rno??miR-222 miRNA Antagomir

MNR01333 2 x 5.0 nmol
EUR 329

mmu-miR-222 miRNA Inhibitor

MIM01544 2 x 5.0 nmol
EUR 176

rno??miR-222 miRNA Inhibitor

MIR01333 2 x 5.0 nmol
EUR 176

mmu-miR-222-3p Primers

MPM01029 150 ul / 10 uM
EUR 121

mmu-miR-222-5p Primers

MPM01030 150 ul / 10 uM
EUR 121

hsa-miR-222 miRNA Antagomir

MNH01588 2 x 5.0 nmol
EUR 329

Anti-ZDHHC1 (aa213-222) antibody

STJ72388 100 µg
EUR 260

MB-02 Plain plate 2mm thickness 1 set

2393036 15unit
EUR 311
Description: 2 pl at es

Tubulin-alpha (Microtubule Marker); Clone TU-02 (Concentrate)

RA0324-C.1 0.1 ml
EUR 125

Tubulin-alpha (Microtubule Marker); Clone TU-02 (Concentrate)

RA0324-C.5 0.5 ml
EUR 300

Recombinant P. vivax MSP1-cap [His]

DAGA-222 1 mg
EUR 441

HIV-1 gp120 and gp41 Chimeric Antigen (8 kDa, Capture)

DAGF-222 1mg
EUR 681

Rabbit Anti-ACTA1 monoclonal antibody, clone KK10-30

DCABH-222 100 ul
EUR 777

Recombinant Human CD93 Protein-6His-ABP tag

CTP-222 100ug Ask for price
Description: A 30 kDa recombinant human CD93 protein Antigen with a N-terminal His6-ABP tag expressed in E. Coli.

CytoSelect 96-Well Phagocytosis Assay (E. coli, Colorimetric Format)

CBA-222 96 assays
EUR 693
Description: Phagocytosis can be assayed by measuring the engulfment of a cell "substrate". However, traditional assays require tedious cell counting under a microscope. Our CytoSelect 96-Well Phagocytosis Assay, E. coli Substrate provides a more accurate, user-friendly, high-throughput alternative to the standard phagocytosis assay. The assay may be adapted for use with 24-well or 48-well plates.

MAPK1/3 (Ab-205/222) Antibody

33303-100ul 100ul
EUR 252

MAPK1/3 (Ab-205/222) Antibody

33303-50ul 50ul
EUR 187

MAPKAPK-2 (Phospho-Thr221/222) Antibody

13158-100ul 100ul
EUR 252

MAPKAPK-2 (Phospho-Thr221/222) Antibody

13158-50ul 50ul
EUR 187

MAPK1/3 (Phospho-Tyr205/222) Antibody

11825-100ul 100ul
EUR 252

In conclusion, the novel model, using 8 laboratory and non-laboratory variables, performed well in risk stratifying patients with suspected chest pain regarding the presence of obstructive-CAD in the present Chinese cohort.