A Novel Laboratory-Based Model to Predict the Presence of Obstructive Coronary Artery Disease.

Commonly used tools to assess the probability of obstructive-coronary artery disease (CAD) were derived based on Caucasian cohorts, with their performance in China is still unknown.

Furthermore, most were established based on non-laboratory variables, contributing to the limited predictive ability to some extent. Thus, we developed and internally validated a laboratory-based model with data from a Chinese cohort of 8963 inpatients, with suspected stable chest pain, referred to catheter-based coronary angiography (CAG) from September 2007 to April 2019, and then compared the present model’s performance with the four most commonly used prediction tools, Coronary Artery Disease Consortium 1/2 Score (CAD1/2), Duke clinical score (DCS), and Diamond-Forrester score (DF).

The final model was developed by random forest method, including 8 predictors derived from 70 variables. Five-fold cross-validation was performed to evaluate the model’s prediction accuracy. In the external validation set, the present model showed a superior area under the receiver-operating curve (0.816), followed by DCS (0.66), CAD2 (0.61), CAD1 (0.59) and at last DF (0.58), respectively.

Furthermore, the present model correctly classified 74.4% of obstructive-CAD patients as high-risk, and correctly classified more than one third of non-obstructive-CAD patients as low-risk.

The present model’s net reclassification improvement (NRI) showed a significant positive reclassification over CAD1 (NRI = 0.60, P < 0.001), DF (NRI = 0.59, P < 0.001), CAD2 (NRI = 0.57, P < 0.001), and DCS (NRI = 0.43, P < 0.001). Decision curve analysis demonstrated that the present model provided a larger net benefit compared with CAD1/2, DCS, and DF.

UCN-02
HY-108262 1mg
EUR 727

TA-02
HY-100115 10mM/1mL
EUR 404

UCN-02
U006-1MG 1 mg
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UCN-02
U006-5MG 5 mg
EUR 1082

TA 02
B4924-10 10 mg
EUR 299

TA 02
B4924-5.1 10 mM (in 1mL DMSO)
EUR 177

TA 02
B4924-50 50 mg
EUR 1095

PU 02
B5687-10 10 mg
EUR 229

PU 02
B5687-25 25 mg
EUR 476

PU 02
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EUR 144

PU 02
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EUR 806

UCN-02
C4829-1 1 mg
EUR 460
Description: UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].

UCN-02
C4829-5 5 mg
EUR 1488
Description: UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].

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EUR 566

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B1215-5
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ELX-02 disulfate
HY-114231B 5mg
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1961358-02-0
TBW00994 10mg Ask for price

145867-02-3
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VX-222 (VCH-222, Lomibuvir)
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VX-222 (VCH-222, Lomibuvir)
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Monoclonal LST1 Antibody (clone LST1/02), Clone: LST1/02
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JH-VIII-157-02
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VX-222
E1KS1480 5mg
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QX 222
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5-IAF [5-Iodoacetamidofluorescein] *CAS 63368-54-7*
222 25 mg
EUR 219

miRZip-222 anti-miR-222 microRNA construct
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Z-IETD-AFC *CAS 219138-02-0*
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21030 1 mg
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Indo-1, AM *CAS 112926-02-0*
21033 50 mg
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hsa-miR-222 miRNA Antagomir
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Cytokeratin 222 Pseudogene Blocking Peptide
33R-2575 100 ug
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70R-34260 100 ug
EUR 327
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70R-34647 100 ug
EUR 327
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MB-02 Plain plate 2mm thickness 1 set
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Description: 2 pl at es

Tubulin-alpha (Microtubule Marker); Clone TU-02 (Concentrate)
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HIV-1 gp120 and gp41 Chimeric Antigen (8 kDa, Capture)
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EUR 681

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EUR 777

CytoSelect 96-Well Phagocytosis Assay (E. coli, Colorimetric Format)
CBA-222 96 assays
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IL-17F Recombinant Protein
11-222 0.05 mg
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Description: Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

SARS Coronavirus Envelope (HSZ-Cc) Recombinant Protein
20-222 0.1 mg
EUR 605.75
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TNF-alpha, Soluble Recombinant Protein
90-222 50 ug
EUR 390.5
Description: Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (MultimericTNF-alpha (Prod. No. AG-40B-0019). Since the MultimericTNF-alpha mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha can be used.

OTUB2 Recombinant Protein
91-222 0.05 mg
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Description: Ubiquitin Thioesterase OTUB2 belongs to the peptidase C65 family, functions as a hydrolase that can remove conjugated ubiquitin from proteins in vitro, may plays an important regulatory role at the level of protein turnover by preventing degradation. OTUB2 is expressed at higher levels in the brain.

Sentrin-specific protease 2 Recombinant Protein
92-222 0.05 mg
EUR 311.75
Description: SENP2 is an enzyme that belongs to the peptidase C48 family. SENP2 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SUMO1 is a small ubiquitin-like protein that can be covalently conjugated to other proteins. It has been implicated as a down-regulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway.

In conclusion, the novel model, using 8 laboratory and non-laboratory variables, performed well in risk stratifying patients with suspected chest pain regarding the presence of obstructive-CAD in the present Chinese cohort.