Despite the remarkable microbial diversity found within humans, our ability to link genes to phenotypes is based upon a handful of model microorganisms. We report a comparative genomics platform for Eggerthella lenta and other Coriobacteriia, a neglected taxon broadly relevant to human health and disease.
We uncover extensive genetic and metabolic diversity and validate a tool for mapping phenotypes to genes and sequence variants. We also present a tool for the quantification of strains from metagenomic sequencing data, enabling the identification of genes that predict bacterial fitness. Competitive growth is reproducible under laboratory conditions and attributable to intrinsic growth rates and resource utilization.
CaCCinh-A01 |
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| B5747-10 | ApexBio | 10 mg | EUR 127 |
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Description: calcium-activated chloride channel (CaCC) inhibitor |
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CaCCinh-A01 |
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| B5747-100 | ApexBio | 100mg | EUR 846 |
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Description: calcium-activated chloride channel (CaCC) inhibitor |
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CaCCinh-A01 |
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| B5747-25 | ApexBio | 25 mg | EUR 266 |
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Description: calcium-activated chloride channel (CaCC) inhibitor |
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CaCCinh-A01 |
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| B5747-5 | ApexBio | 5 mg | EUR 70 |
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Description: calcium-activated chloride channel (CaCC) inhibitor |
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CaCCinh-A01 |
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| B5747-50 | ApexBio | 50 mg | EUR 475 |
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Description: calcium-activated chloride channel (CaCC) inhibitor |
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CaCCinh-A01 |
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| 555104 | MedKoo Biosciences | 10.0mg | EUR 90 |
T16Ainh-A01 |
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| 555877 | MedKoo Biosciences | 10.0mg | Ask for price |
CaCCinh-A01 |
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| HY-100611 | MedChemExpress | 50mg | EUR 622.8 |
T16Ainh-A01 |
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| T13059-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: T16Ainh-A01 |
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T16Ainh-A01 |
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| T13059-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: T16Ainh-A01 |
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T16Ainh-A01 |
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| T13059-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: T16Ainh-A01 |
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T16Ainh-A01 |
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| T13059-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: T16Ainh-A01 |
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T16Ainh-A01 |
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| T13059-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: T16Ainh-A01 |
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CaCCinh-A01 |
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| T4330-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: CaCCinh-A01 |
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CaCCinh-A01 |
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| T4330-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: CaCCinh-A01 |
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CaCCinh-A01 |
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| T4330-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: CaCCinh-A01 |
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CaCCinh-A01 |
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| T4330-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: CaCCinh-A01 |
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CaCCinh-A01 |
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| T4330-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: CaCCinh-A01 |
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CaCCinh-A01 |
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| abx282431-100g | Abbexa | 100 µg | Ask for price |
CaCCinh-A01 |
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| abx282431-20g | Abbexa | 20 µg | EUR 118.75 |
CaCCinh-A01 |
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| abx282431-50g | Abbexa | 50 µg | EUR 312.5 |
Smurf1-IN-A01 |
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| 562970 | MedKoo Biosciences | 200.0mg | EUR 750 |
Smurf1-IN-A01 |
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| HY-110195 | MedChemExpress | 10mg | EUR 267.6 |
Smurf1-IN-A01 |
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| T16904-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Smurf1-IN-A01 |
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Smurf1-IN-A01 |
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| T16904-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Smurf1-IN-A01 |
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Smurf1-IN-A01 |
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| T16904-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Smurf1-IN-A01 |
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Smurf1-IN-A01 |
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| T16904-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Smurf1-IN-A01 |
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Smurf1-IN-A01 |
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| T16904-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Smurf1-IN-A01 |
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JIB-04 |
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| 406601 | MedKoo Biosciences | 200.0mg | EUR 1250 |
JIB-04 |
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| B1579-20 | ApexBio | 20 mg | EUR 102 |
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Description: Jumonji histone demethylase inihibitor |
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JIB-04 |
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| B1579-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 68 |
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Description: Jumonji histone demethylase inihibitor |
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JIB-04 |
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| B1579-50 | ApexBio | 50 mg | EUR 190 |
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Description: Jumonji histone demethylase inihibitor |
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JIB-04 |
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| HY-13953 | MedChemExpress | 50mg | EUR 548.4 |
JIB-04 |
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| T1868-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: JIB-04 |
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JIB-04 |
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| T1868-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: JIB-04 |
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JIB-04 |
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| T1868-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: JIB-04 |
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JIB-04 |
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| T1868-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: JIB-04 |
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JIB-04 |
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| T1868-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: JIB-04 |
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WEHL-04 |
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| T22458-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: WEHL-04 |
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WEHL-04 |
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| T22458-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: WEHL-04 |
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WEHL-04 |
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| T22458-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: WEHL-04 |
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WEHL-04 |
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| T22458-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: WEHL-04 |
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WEHL-04 |
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| T22458-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: WEHL-04 |
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SDR-04 |
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| T60996-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: SDR-04 |
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SDR-04 |
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| T60996-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: SDR-04 |
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SDR-04 |
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| T60996-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: SDR-04 |
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SDR-04 |
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| T60996-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: SDR-04 |
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SDR-04 |
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| T60996-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: SDR-04 |
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JIB-04 |
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| abx282440-100g | Abbexa | 100 µg | Ask for price |
JIB-04 |
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| abx282440-20g | Abbexa | 20 µg | EUR 131.25 |
JIB-04 |
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| abx282440-50g | Abbexa | 50 µg | EUR 300 |
RTI-113 |
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| R701110 | Toronto Research Chemicals | 50mg | EUR 187 |
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Description: 141807-57-0 |
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SI-113 |
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| T9589-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: SI-113 |
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SI-113 |
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| T9589-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: SI-113 |
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SI-113 |
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| T9589-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: SI-113 |
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SI-113 |
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| T9589-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: SI-113 |
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SI-113 |
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| T9589-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: SI-113 |
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FAUC-113 |
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| T25407-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: FAUC-113 |
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FAUC-113 |
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| T25407-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: FAUC-113 |
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FAUC-113 |
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| T25407-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: FAUC-113 |
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FAUC-113 |
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| T25407-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: FAUC-113 |
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FAUC-113 |
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| T25407-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: FAUC-113 |
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P-113 |
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| T25913-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: P-113 |
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P-113 |
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| T25913-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: P-113 |
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P-113 |
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| T25913-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: P-113 |
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P-113 |
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| T25913-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: P-113 |
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P-113 |
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| T25913-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: P-113 |
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A 113 |
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| T29491-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: A 113 |
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A 113 |
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| T29491-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: A 113 |
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A 113 |
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| T29491-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: A 113 |
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A 113 |
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| T29491-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: A 113 |
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A 113 |
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| T29491-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: A 113 |
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Ro 04-6790 |
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| B7216-10 | ApexBio | 10 mg | EUR 223 |
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Description: 5-HT6 receptor antagonist |
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Ro 04-6790 |
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| B7216-50 | ApexBio | 50 mg | EUR 920 |
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Description: 5-HT6 receptor antagonist |
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Ro 04-6790 |
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| R700873 | Toronto Research Chemicals | 100mg | EUR 276 |
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Description: 202466-68-0 |
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Ro 04-5595 |
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| R700893 | Toronto Research Chemicals | 500mg | EUR 7600 |
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Description: 194089-07-1 |
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(Z)-JIB-04 |
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| T1816-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: (Z)-JIB-04 |
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(Z)-JIB-04 |
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| T1816-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: (Z)-JIB-04 |
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(Z)-JIB-04 |
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| T1816-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: (Z)-JIB-04 |
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(Z)-JIB-04 |
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| T1816-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: (Z)-JIB-04 |
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(Z)-JIB-04 |
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| T1816-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: (Z)-JIB-04 |
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BSJ-04-132 |
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| T35476-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: BSJ-04-132 |
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BSJ-04-132 |
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| T35476-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: BSJ-04-132 |
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BSJ-04-132 |
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| T35476-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: BSJ-04-132 |
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BSJ-04-132 |
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| T35476-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: BSJ-04-132 |
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BSJ-04-132 |
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| T35476-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: BSJ-04-132 |
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Ro 04-6790 |
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| T23240-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Ro 04-6790 |
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Ro 04-6790 |
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| T23240-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Ro 04-6790 |
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Ro 04-6790 |
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| T23240-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Ro 04-6790 |
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Ro 04-6790 |
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| T23240-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Ro 04-6790 |
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Ro 04-6790 |
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| T23240-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Ro 04-6790 |
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YKL-04-085 |
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| T29176-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: YKL-04-085 |
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YKL-04-085 |
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| T29176-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: YKL-04-085 |
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YKL-04-085 |
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| T29176-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: YKL-04-085 |
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YKL-04-085 |
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| T29176-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: YKL-04-085 |
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YKL-04-085 |
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| T29176-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: YKL-04-085 |
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155734-04-6 |
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| TBZ1243 | ChemNorm | unit | Ask for price |
Recombinant CD37 Protein (Ala 113-Apn 240) [Fc] |
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| VAng-1279Lsx-1mg | Creative Biolabs | 1 mg | EUR 6592.8 |
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Description: Human CD37, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAI06753) |
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Recombinant CD37 Protein (Ala 113-Apn 240) [Fc] |
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| VAng-1279Lsx-50g | Creative Biolabs | 50 µg | EUR 1099.2 |
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Description: Human CD37, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAI06753) |
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CREB327 (113 - 126) |
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| 5-01003 | CHI Scientific | 4 x 5mg | Ask for price |
pVITRO1-SS-113 |
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| PVT18241 | Lifescience Market | 2 ug | EUR 360 |
113-Trimethylcyclohexane - 1ML |
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| S-3723 | Scientific Laboratory Supplies | 1ML | EUR 209.25 |
P-113 acetate |
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| T25913L-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: P-113 acetate |
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P-113 acetate |
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| T25913L-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: P-113 acetate |
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P-113 acetate |
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| T25913L-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: P-113 acetate |
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P-113 acetate |
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| T25913L-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: P-113 acetate |
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P-113 acetate |
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| T25913L-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: P-113 acetate |
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Antibacterial agent 113 |
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| T63252-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Antibacterial agent 113 |
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Antibacterial agent 113 |
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| T63252-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Antibacterial agent 113 |
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Antibacterial agent 113 |
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| T63252-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Antibacterial agent 113 |
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Antibacterial agent 113 |
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| T63252-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Antibacterial agent 113 |
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Unique signatures of in vivo competition in gnotobiotic mice include an adhesin enriched in poor colonizers. Together, these computational and experimental resources represent a strong foundation for the continued mechanistic dissection of the Coriobacteriia and a template that can be applied to study other genetically intractable taxa.